Which action would the nurse implement when a client develops an anaphylactic reaction?

Learning Outcome

  1. Recall three foods that cause allergies

  2. Describe the presentation of food allergies

  3. Summarize the treatment of food allergy

  4. List the nursing management of anaphylaxis caused by peanuts

Introduction

Food allergy is defined as an immune reaction to proteins in the food and can be immunoglobulin (Ig)E-mediated or non–IgE-mediated. IgE-mediated food allergy is a worldwide health problem that affects millions of persons and numerous aspects of a person’s life. Allergic reactions secondary to food ingestion are responsible for a variety of symptoms involving the skin, gastrointestinal tract, and respiratory tract. Prevalence rates are uncertain, but the incidence appears to have increased over the past three decades, primarily in countries with a Western lifestyle.[1][2][3]

Nursing Diagnosis

  • Dyspnea

  • Chest tightness

  • Stomach cramps

  • Dizzy

  • Swollen lips and tongue

  • Feeling a sense of doom

  • Rash

  • Hoarse voice

  • Pale

Causes

Food allergies can have two etiologies depending on the mechanism of disease: IgE-mediated or type I hypersensitivity and other immunologically non-IgE mediated reactions.[4][5]

Risk Factors

About 6% of children experience food allergic reactions in the first three years of life, including approximately 2.5% with cow’s milk allergy, 1.5% with egg allergy, and 1% with peanut allergy. Studies have shown that peanut allergy prevalence increased over the past decade. Most children tend to outgrow milk and egg allergies by school-age. In contrast, children with peanut, nut, or seafood allergy retain their allergy for life.[6][7]

Assessment

Clinical Manifestations

According to the predominant target organ and immune mechanism, it is most useful to subdivide food hypersensitivity disorders (Table 1).

Table 1- Symptoms of Food-Induced Allergic Reactions

Gastrointestinal

Food allergies that cause gastrointestinal manifestations are often the initial form of allergy to affect infants and young children, causing irritability, vomiting or “spitting-up,” diarrhea, and poor weight gain. There are three main entities related to food allergies associated with gastrointestinal symptoms

  • Food protein-induced enterocolitis syndrome (FPIES): these patients can present with emesis one to three hours after feeding, and constant exposure might result in abdominal distention, bloody diarrhea, anemia, and faltering weight and are provoked by cow’s milk or soy protein-based formulas.

  • Food protein-induced proctocolitis is known to cause blood-streaked stools in otherwise healthy infants in the first few months of life and is associated with breastfed infants.

  • Food protein-induced enteropathy is associated with steatorrhea and poor weight gain in the first several months of life.

Skin

  • Atopic dermatitis, also known as eczema, is linked to asthma and allergic rhinitis, and about 30% of children with moderate to severe atopic dermatitis have food allergies.

  • Acute urticaria and angioedema are one of the most common symptoms of food allergic reactions and tend to have very rapid onset after the responsible allergen is ingested. Most likely foods include egg, milk, peanuts, and nuts, but sesame and poppy seeds and fruits such as kiwi have been linked.

  • Perioral dermatitisis benign and is regularly a contact dermatitis caused by substances in toothpaste, gum, lipstick, or medications. These tend to resolve spontaneously.

Respiratory

  • Respiratory food allergies are uncommon as isolated symptoms. Wheezing occurs in approximately 25% of IgE-mediated food allergic reactions, but only approximately 10% of asthmatic patients have food-induced respiratory symptoms.

Evaluation

When suspecting a food allergy, the diagnostic approach begins with a careful medical history and physical examination. The history is particularly key in assessing a particular acute reaction such as systemic anaphylaxis, but also for attempting to establish which food was involved and what allergic mechanism is likely. A diet diary often can be helpful to supplement a medical history, especially in chronic disorders, as it identifies the specific food causing symptoms. A focused physical is also important, as an examination of the patient may provide signs consistent with an allergic reaction or disorder often associated with food allergy.[8][9]

When the history does not reveal the causative food allergen, allergy testing can be performed. For IgE-mediated disorders, skin prick tests (SPTs) provide a rapid means to detect sensitization to a specific food but has advantages and disadvantages as a positive test suggests the possibility of reactivity to a specific food, around 60% of positive tests do not reflect symptomatic food allergy. In contrast, a negative skin-prick establishes the absence of an IgE-mediated reaction. Therefore more definitive tests, such as quantitative IgE tests or food elimination and challenge, are often necessary to establish a diagnosis of food allergy.

Serum tests to determine food-specific IgE antibodies (e.g., RASTs) offer additional modality to assess IgE-mediated food allergy. Increasingly higher concentrations of food-specific IgE correlate with an increased likelihood of a clinical reaction. When a patient has a food-specific IgE level exceeding the predictive (diagnostic) values, he or she is more than 95% likely to experience an allergic reaction.

On the other hand, a provocative oral challenge is needed to establish whether a patient has hypersensitivity to a particular food, and the double-blind, placebo-controlled challenge is the gold standard for food allergy diagnosis. Suspect foods should be eliminated for 7 to 14 days before challenge, and longer in some non-IgE-mediated gastrointestinal disorders, to increase the likelihood of a non-equivocal food challenge result. Also, medications that could interfere with the evaluation of food-induced symptoms (e.g., antihistamines and b-adrenergic bronchodilators) must be discontinued. If symptoms remain unchanged despite appropriate elimination diets, it is unlikely that food allergy is accountable for the child’s disorder. If the blinded challenge result is negative, it must be confirmed using an open and supervised feeding of a typical serving of the food to rule out a false-negative challenge result that can occur in approximately 1% to 3% of the cases.

Medical Management

Once the diagnosis of food hypersensitivity is established, the only proven therapy remains elimination of the offending allergen, with the absence of a cure. Parents and children affected with food allergy require extensive education, including specific instruction on understanding food labels, restaurant meals, and risky behaviors leading to unexpected reactions. Patients at risk for anaphylaxis must be trained to recognize initial symptoms promptly and should be instructed on the proper use of auto-injectable epinephrine and have epinephrine and antihistamines accessible at all times.[10][11][12]

Patients with food allergy with asthma or a past history of severe reaction or reaction to peanuts, nuts, seeds, or seafood should be given self-injectable epinephrine and a written emergency plan for treatment of an unintentional ingestion. Clinical tolerance develops to most food allergens over time, except for peanuts, nuts, and seafood. Children with low levels of peanut-specific IgE should be reexamined to determine whether they have outgrown their allergy.

Prevention of Food Allergy

Currently, the recommendations are to introduce complementary solid foods, such as egg, peanut products, fish, wheat, and other allergenic foods one at a time after four to six months of age when breastfeeding, as there is no need to avoid or delay their introduction.

Nursing Management

  • Administer Epinephrine if the patient has anaphylaxis

  • Provide oxygen

  • Start 2 large-bore IVs

  • Monitor respiration and prepare for intubation

  • Educate patients on the avoidance of allergic foods

  • Be ready to perform CPR

  • Monitor vital signs

  • Teach the patient to wear an ID bracelet

  • Educate patient to carry Epipen autoinjector

  • Teach patient and caregiver to read labels before buying food

When To Seek Help

  • If apnea

  • Abnormal vitals

  • Cyanotic

  • Decreased oxygenation

  • Swollen lips and tongue

  • Unresponsive

Outcome Identification

Avoiding all allergic foods

Monitoring

  • Administer Epinephrine if the patient has anaphylaxis

  • Provide oxygen

  • Start 2 large-bore IVs

  • Monitor respiration and prepare for intubation

  • Educate patients on the avoidance of allergic foods

  • Be ready to perform CPR

  • Monitor vital signs

  • Teach the patient to wear an ID bracelet

  • Educate patient to carry Epipen autoinjector

  • Teach patient and caregiver to read labels before buying food

Coordination of Care

Food allergies have become a problem in society. Even though the risk of anaphylaxis is rare, there is hysteria over certain foods in schools, hotels, and in many public places. The key is to educate the patient. All patients with a documented food allergy should be educated by the nurse to carry a self-injectable device that contains epinephrine. This device needs to be stored properly. The school nurse should provide the student with education on how and when to use the device. Older patients may be educated on the benefits of carrying an antihistamine in syrup or chewable form. More important, the pharmacist should educate the caregiver on how to use the epinephrine containing devices and how to identify an allergic reaction. The key is to avoid the allergen. A dietary consult is recommended so that the patient and the caregiver can be taught to identify food allergens and eliminate them from the diet. [2][13](Level V)

Outcomes

The majority of infants and young children develop tolerance to their food allergies with time. Most children outgrow their allergies to eggs, milk, and soy within 3-5 years. However, there are also reports that more than 50% of children will continue to have food allergies that persist to puberty. However, over time, even these children will develop tolerance to their allergies by the end of the second decade of life. Children who have non-IgE mediated food allergies such as enterocolitis usually have a cessation of their disorder within the first few years after birth.  Unfortunately, children with eosinophilic esophagitis may have symptoms that continue to persist. Severe anaphylactic reactions with food allergies are rare but do occur. The fatalities are usually seen in school children and the foods implicated include shellfish, peanuts, and fish. [14][15](Level V)

Health Teaching and Health Promotion

  • Educate patient to carry Epipen

  • Educate patient on avoiding allergic foods

  • Educate patient on wearing an ID bracelet

Risk Management

Food allergies have become a problem in society. Even though the risk of anaphylaxis is rare, there is hysteria over certain foods in schools, hotels, and in many public places. Parents and travelers have become demanding about foods, often resulting in major league arguments. The key is to educate the patient and caregiver. Managing food allergies requires an interprofessional team dedicated to the care of children. The key is to avoid the allergen; failure to do so can lead to medical malpractice if the child was to suffer a fatal anaphylactic reaction.

Discharge Planning

All patients with a documented food allergy should be educated by the nurse to carry a self-injectable device that contains epinephrine. This device needs to be stored properly. The school nurse should provide the student with education on how and when to use the device. Older patients may be educated on the benefits of carrying an antihistamine in syrup or chewable form. More important, the pharmacist should educate the caregiver on how to use the epinephrine containing devices and how to identify an allergic reaction. The key is to avoid the allergen. A dietary consult is recommended so that the patient and the caregiver can be taught to identify food allergens and eliminate them from the diet. Parents should be educated about reading labels on foods and how to identify allergens.  [2][13](Level V)

Evidence-Based Issues

The majority of infants and young children develop tolerance to their food allergies with time. Most children outgrow their allergies to eggs, milk, and soy within 3-5 years. However, there are also reports that more than 50% of children will continue to have food allergies that persist to puberty. However, over time, even these children will develop tolerance to their allergies by the end of the second decade of life. Children who have non-IgE mediated food allergies such as enterocolitis usually have a cessation of their disorder within the first few years after birth.  Unfortunately, children with eosinophilic esophagitis may have symptoms that continue to persist. Severe anaphylactic reactions with food allergies are rare but do occur. The fatalities are usually seen in school children and the foods implicated include shellfish, peanuts, and fish. [14][15](Level V)

Pearls and Other issues

Food allergic reactions are the most common cause of anaphylaxis seen in hospital emergency departments in the United States. Anaphylaxis is a potentially fatal allergic reaction that occurs rapidly and involves multiple systems including cutaneous, cardiovascular, respiratory, and gastrointestinal symptom.

Review Questions

Which action would the nurse implement when a client develops an anaphylactic reaction?

Figure

Symptoms of Food-Induced Allergic Reactions. Contributed by Claudia Lopez, MD

References

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Loh W, Tang MLK. The Epidemiology of Food Allergy in the Global Context. Int J Environ Res Public Health. 2018 Sep 18;15(9) [PMC free article: PMC6163515] [PubMed: 30231558]

2.

Dinakar C, Warady B. Food Allergy Care: "It Takes a Team". Mo Med. 2016 Jul-Aug;113(4):314-319. [PMC free article: PMC6139929] [PubMed: 30228485]

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Pham MN, Bunyavanich S. Prenatal Diet and the Development of Childhood Allergic Diseases: Food for Thought. Curr Allergy Asthma Rep. 2018 Sep 18;18(11):58. [PubMed: 30229317]

4.

Budimir J, Mravak-Stipetić M, Bulat V, Ferček I, Japundžić I, Lugović-Mihić L. Allergic reactions in oral and perioral diseases-what do allergy skin test results show? Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Jan;127(1):40-48. [PubMed: 30228058]

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Chang KL, Guarderas JC. Allergy Testing: Common Questions and Answers. Am Fam Physician. 2018 Jul 01;98(1):34-39. [PubMed: 30215951]

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Rial MJ, Sastre J. Food Allergies Caused by Allergenic Lipid Transfer Proteins: What Is behind the Geographic Restriction? Curr Allergy Asthma Rep. 2018 Sep 11;18(11):56. [PubMed: 30206718]

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Shroba J, Rath N, Barnes C. Possible Role of Environmental Factors in the Development of Food Allergies. Clin Rev Allergy Immunol. 2019 Dec;57(3):303-311. [PubMed: 30159849]

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Ramesh M, Karagic M. New modalities of allergen immunotherapy. Hum Vaccin Immunother. 2018;14(12):2848-2863. [PMC free article: PMC6343630] [PubMed: 30183485]

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Lacombe-Barrios J, Gómez F, Pérez N, Barrionuevo E, Doña I, Fernández Tahía D, Mayorga C, Torres MJ, Moreno E, Bogas B, Salas M. Accuracy of the Diagnosis of Allergic Reactions in the Emergency Department. J Investig Allergol Clin Immunol. 2019;29(3):222-230. [PubMed: 30183657]

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Boudreau-Romano S, Qamar N. Peanut Allergy: Changes in Dogma and Past, Present, and Future Directions. Pediatr Ann. 2018 Jul 01;47(7):e300-e304. [PubMed: 30001445]

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Deschildre A, Lejeune S. How to cope with food allergy symptoms? Curr Opin Allergy Clin Immunol. 2018 Jun;18(3):234-242. [PubMed: 29608467]

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Muñoz VL. 'Everybody has to think - do I have any peanuts and nuts in my lunch?' School nurses, collective adherence, and children's food allergies. Sociol Health Illn. 2018 May;40(4):603-622. [PubMed: 29516530]

13.

Pajno GB, Fernandez-Rivas M, Arasi S, Roberts G, Akdis CA, Alvaro-Lozano M, Beyer K, Bindslev-Jensen C, Burks W, Ebisawa M, Eigenmann P, Knol E, Nadeau KC, Poulsen LK, van Ree R, Santos AF, du Toit G, Dhami S, Nurmatov U, Boloh Y, Makela M, O'Mahony L, Papadopoulos N, Sackesen C, Agache I, Angier E, Halken S, Jutel M, Lau S, Pfaar O, Ryan D, Sturm G, Varga EM, van Wijk RG, Sheikh A, Muraro A., EAACI Allergen Immunotherapy Guidelines Group. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. Allergy. 2018 Apr;73(4):799-815. [PubMed: 29205393]

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16.

Yrjänä JMS, Koski T, Törölä H, Valkama M, Kulmala P. Very early introduction of semisolid foods in preterm infants does not increase food allergies or atopic dermatitis. Ann Allergy Asthma Immunol. 2018 Sep;121(3):353-359. [PubMed: 29981439]

What to do if a patient has an anaphylactic reaction?

What to do in an emergency.
Call 911 or emergency medical help..
Use an epinephrine autoinjector, if available, by pressing it into the person's thigh..
Make sure the person is lying down and elevate the legs..
Check the person's pulse and breathing and, if necessary, administer CPR or other first-aid measures..

What is the first thing you should do when a patient is having an anaphylactic reaction NHS?

Call 999 for an ambulance immediately (even if they start to feel better) – mention that you think the person has anaphylaxis. Remove any trigger if possible – for example, carefully remove any stinger stuck in the skin.

What is the first nursing action in response to suspected anaphylaxis?

Epinephrine — Epinephrine is the first and most important treatment for anaphylaxis, and it should be administered as soon as anaphylaxis is recognized to prevent the progression to life-threatening symptoms as described in the rapid overviews of the emergency management of anaphylaxis in adults (table 1) and children ...

What does the nurse do when anaphylaxis is suspected?

The management of a patient with anaphylaxis should start with the removal of exposure to the known or suspected trigger, if still possible [51], followed by the assessment of patient's circulation, airway patency, breathing, mental status, skin, and, if possible, weight [44] (Fig. 1).