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posted on 19.02.2013, 23:11 authored by Jan Rossaint, Christian Berger, Hugo Van Aken, Hans H. Scheld, Peter K. Zahn, Andreas Rukosujew, Alexander Zarbock

Values are presented as mean +/− SEM or numbers of patients. MI: myocardial infarction. ICU: intensive care unit. n.s.: not significant.

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Open Access

Peer-reviewed

Research Article

  • Christian Berger,
  • Hugo Van Aken,
  • Hans H. Scheld,
  • Peter K. Zahn,
  • Andreas Rukosujew,
  • Alexander Zarbock

Cardiopulmonary Bypass during Cardiac Surgery Modulates Systemic Inflammation by Affecting Different Steps of the Leukocyte Recruitment Cascade

  • Jan Rossaint, 
  • Christian Berger, 
  • Hugo Van Aken, 
  • Hans H. Scheld, 
  • Peter K. Zahn, 
  • Andreas Rukosujew, 
  • Alexander Zarbock

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  • Published: September 19, 2012
  • //doi.org/10.1371/journal.pone.0045738

About the Authors

Jan Rossaint

Affiliation Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany

Christian Berger

Affiliation Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany

Hugo Van Aken

Affiliation Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany

Hans H. Scheld

Affiliation Department of Thoracic and Cardiovascular Surgery, University Hospital Münster, Münster, Germany

Peter K. Zahn

Affiliation Department of Anesthesiology, Intensive Care Medicine, Palliative Care Medicine and Pain Management, University Hospital Bergmannsheil Bochum, Bochum, Germany

Andreas Rukosujew

Affiliation Department of Thoracic and Cardiovascular Surgery, University Hospital Münster, Münster, Germany

Alexander Zarbock

* E-mail:

Affiliation Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PKZ AZ. Performed the experiments: JR CB. Analyzed the data: JR CB AZ. Wrote the paper: JR AZ. Equally contributed to this work and share first authorship: JR CB. Equally contributed to this work and share senior authorship: AR AZ. Revised the manuscript: HVA HHS PKZ.

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Post-implantation syndrome after frozen elephant trunk is associated with the volume of new-onset aortic thrombus

Citation Format  

@article{JTD54007, author = {Abdulhakim Ibrahim and Elena Marchiori and Thorsten Eierhoff and Sven Martens and Arash Motekallemi and Andreas Rukosujew and Alexander Oberhuber and Giuseppe Asciutto}, title = {Post-implantation syndrome after frozen elephant trunk is associated with the volume of new-onset aortic thrombus}, journal = {Journal of Thoracic Disease}, volume = {13}, number = {7}, year = {2021}, keywords = {}, abstract = {}, issn = {2077-6624}, url = {//jtd.amegroups.com/article/view/54007} }


Single-Center Experience With the Thoraflex™ Hybrid Prosthesis: Indications, Implantation Technique and Results

Konrad Wisniewski et al. Front Cardiovasc Med. 2022.

Free PMC article

Abstract

Objective: The aim of this study was to evaluate the early and mid-term results after the frozen elephant trunk (FET) procedure for the treatment of complex arch and proximal descending aortic disease in a single-center institution.

Methods: From April 2015 to July 2021, 72 patients (25 women, 60.4 ± 10.3 years) underwent Thoraflex™ Hybrid implantation at our institution. The indications were thoracic aortic aneurysm (TAA) (n = 16, 22.2%), post-dissection aneurysm (n = 21, 29.2%), and acute aortic dissection (AAD) (n = 35, 48.6%). Antegrade cerebral perfusion under moderate hypothermia (28°C) was employed in all cases. Eighteen patients (25%) have already been operated due to heart or aortic disease.

Results: Overall in-hospital mortality was 12.5% (9 patients). Rates of permanent neurological dysfunction and spinal cord injury were 9.7 and 5.5%, respectively. The in-hospital mortality rate among patients operated on AAD, TAA, and post-dissection aneurysm were 8.6, 6.2, and 23.8%, respectively. At a mean follow-up of 26 ± 20 months, mortality was 9.7%. Furthermore, 23 patients (31.9%) required a subsequent procedure in distal aorta: endovascular stentgraft extension in 19 patients (26.4%) and open aortic surgery in 4 patients (5.5%). The mid-term survival of patients with type A aortic dissection was 97%.

Conclusions: Our experience with the Thoraflex Hybrid prosthesis demonstrates its surgical applicability for different types of aortic pathologies with promising outcomes during early and midterm follow-up. Our technique and perioperative management lead to comparable or even superior neurological outcomes and mortality in urgent cases considering other high-volume centers.

Keywords: Thoraflex Hybrid prosthesis; acute aortic dissection (AAD); frozen elephant trunk (FET); post-dissection aneurysm; thoracic aortic aneurysm (TAA).

Copyright © 2022 Wisniewski, Motekallemi, Dell'Aquila, Oberhuber, Schaefers, Ibrahim, Martens and Rukosujew.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1

Intraoperative photography, complete implantation of the Thoraflex Hybrid prosthesis with mechanical conduit.

Figure 2

Three-dimensional computer tomography angiography (CTA) after distal stentgraft extension succeeding after implantation of the Thoraflex Hybrid prosthesis.

Figure 3

The Kaplan–Meier survival curve for the overall surgical population−95% confidence interval [CI] 1,574.015 (1,374.679–1,773.351).

Figure 4

Kaplan–Meier survival curves between all three groups: acute aortic dissection (AAD), thoracic aortic aneurysm (TAA), post-dissection aortic aneurysm (PDAA)−95% CI 1,801.015 (1,585.471–2,018.503), 95% CI 1,390.010 (986.730–1,793.290), 95% CI 1,574.015 (1,374.679–1,773.351), respectively.

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References

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