In the 2000s, a team led by David E. Nichols at Purdue University set to develop a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor.[1] LSZ has little to no history of human usage prior to 2012 when it appeared on some research chemical markets in the UK.[2] LSZ later gained international popularity through a small cluster of mail-order novel psychedelic shops that appeared in 2012.[3] There have also been several unconfirmed reports of LSZ being synthesized in illicit laboratories and distributed on blotter paper or in liquid solution under names such as "Diazedine" and "λ" (or "Lambda").[4][5] LSZ is not considered to be addictive or physiologically toxic.[6][7] Nevertheless, adverse psychological reactions such as severe anxiety, paranoia and psychosis are always possible, particularly among those predisposed to mental illness.[8] It is highly advised to use harm reduction practices if using this substance. ChemistryLSZ, or d-lysergic acid 2,4-dimethylazetidide, is a semi-synthethic alkaloid of the lysergamide famiy. It contains a core structure of lysergic acid with an amine functional group bound to RN of the chemical structure. This core polycyclic structure is an indole derivative, and has tryptamine and phenethylamine groups embedded within it. The structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an amide group is bound. Additionally, the substitutions of the terminal nitrogen atom of the amide group form a 2,4-dimethylazetidide group. LSZ is additionally substituted at carbon 6 with a methyl group. There are three possible stereoisomers around the azetidine ring with the (S,S)-(+) isomer being the most active. It is slightly more potent than LSD itself in drug discrimination tests using trained rats.[1] PharmacologyLSZ likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from LSZ's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism. It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Experience reportsAnecdotal reports which describe the effects of this compound within our experience index include: Additional experience reports can be found here:
Toxicity and harm potentialThe toxicity and long-term health effects of recreational LSZ do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because LSZ is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried LSZ suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this substance. Tolerance and addiction potentialLSZ is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating. Tolerance to the effects of LSZ is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). LSZ presents cross-tolerance with all psychedelics, meaning that all psychedelics will have a reduced effect after the consumption of LSZ. Dangerous interactionsWarning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them). Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
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Was ist der Unterschied zwischen LSD und Acid?Die Abkürzung LSD steht für Lysergsäurediethylamid. Das ist der Wirkstoff dieser Droge. Ein Synonym dafür ist das Kurzwort Acid (englisch für Säure). Acid ist ein anderer Name für LSD.
Was ist der Unterschied zwischen LSD und LSA?LSA ist die Vorläufersubstanz von LSD und produziert dementsprechend ähnliche Effekte. Ein wichtiger Unterschied ist das LSD deutlich potenter als LSA ist. Außerdem ist LSA eine rein natürliche Substanz, während LSD hingegen chemisch synthetisiert werden muss.
Welche LSD Arten gibt es?LSD ist weniger häufig in Form von kleinen Tabletten (Mikrokügelchen, „Mikros“) mit einem Durchmesser von 2–3 mm, dünnen, quadratischen Gelatinestücken („Fensterscheiben“) oder in Kapselform erhältlich. Auch LSD-Lösungen in Wasser oder Alkohol finden sich gelegentlich.
Wie heißt die Droge LSD in der Szene?„Szene-Synonyme“ für LSD sind „Acid“, „Mini Trip“, „Comic Trip“. Der Handel mit LSD ist nach dem Betäubungsmittelgesetz verboten.
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Was ist der unterschied zwischen ald und lsd
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