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Why Does this Site Require Cookies?This site uses cookies to improve performance by remembering that you are logged in when you go from page to page. To provide access without cookies would require the site to create a new session for every page you visit, which slows the system down to an unacceptable level. What Gets Stored in a Cookie?This site stores nothing other than an automatically generated session ID in the cookie; no other information is captured. In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site cannot determine your email name unless you choose to type it. Allowing a website to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it. Thorax. 2005 Mar; 60(3): 226–228. AbstractBackground: Chronic airway obstruction is characteristic of cystic fibrosis (CF) but there are few studies of airway smooth muscle remodelling in CF. Methods: Airway smooth muscle content and mean airway smooth muscle cell size were measured by applying design-based stereology to bronchoscopic biopsy specimens obtained from seven subjects with CF and 15 healthy controls. Results: The smooth muscle content increased by 63% in subjects with CF (mean (SD) 0.173 (0.08) v 0.106 (0.042) mm3 smooth muscle/mm3 submucosa, mean difference –0.067; 95% CI –0.12 to –0.013, p = 0.017) but there was no increase in mean cell size (2705 (351) v 2654 (757) µm3, mean difference –51; 95% CI –687 to 585, p = 0.87). Conclusions: These findings indicate hyperplasia of airway smooth muscle cells without hypertrophy and suggest that accumulation of airway smooth muscle cells may contribute to airway narrowing and bronchial hyperresponsiveness in CF. Full TextThe Full Text of this article is available as a PDF (71K). Selected ReferencesThese references are in PubMed. This may not be the complete list of references from this article.
Articles from Thorax are provided here courtesy of BMJ Publishing Group What are the major pathologic and structural changes associated with cystic fibrosis?The anatomic alterations of the lungs associated with cystic fibrosis may result in both restrictive and obstructive lung characteristics, but excessive bronchial secretions, bronchial obstruction, and hyperinflation of the lungs are the predominant features of cystic fibrosis in the advanced stages.
What is the pathology of cystic fibrosis?In cystic fibrosis, the airways fill with thick, sticky mucus, making it difficult to breathe. The thick mucus is also an ideal breeding ground for bacteria and fungi. Cystic fibrosis (CF) is an inherited disorder that causes severe damage to the lungs, digestive system and other organs in the body.
How can the genetic mutation found with cystic fibrosis be characterized?General Discussion. Cystic fibrosis is a genetic disorder that often affects multiple organ systems of the body. Cystic fibrosis is characterized by abnormalities affecting certain glands (exocrine) of the body especially those that produce mucus.
Which of the following would you expect to find in a patient with cystic fibrosis?Symptoms of CF
Frequent lung infections including pneumonia or bronchitis. Wheezing or shortness of breath. Poor growth or weight gain in spite of a good appetite. Frequent greasy, bulky stools or difficulty with bowel movements.
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