General High Alert Medication: This medication bears a heightened risk of causing significant patient harm when it is used in error. Pronunciation: Trade Name(s) Ther. Class. inotropics Pharm. Class. adrenergics Short-term (<48 hr) management of heart failure caused by depressed contractility from organic heart disease or surgical procedures. Stimulates beta1 (myocardial)-adrenergic
receptors with relatively minor effect on heart rate or peripheral blood vessels. Therapeutic Effect(s): Increased cardiac output without significantly increased heart rate. Absorption: Administered by IV infusion only, resulting in complete bioavailability. Distribution: Unknown. Metabolism and Excretion: Metabolized by the liver and other tissues. Half-life: 2 min. TIME/ACTION
PROFILE (inotropic effects)
Contraindication/Precautions (adsbygoogle = window.adsbygoogle || []).push({});Contraindicated in:
Use Cautiously in:
Adverse Reactions/Side EffectsCV: hypertension, increased heart rate, premature ventricular contractions, angina pectoris, arrhythmias, hypotension, palpitations GI: nausea, vomiting Local: phlebitis Neuro: headache Resp: shortness of breath Misc: hypersensitivity reactions, nonanginal chest pain * CAPITALS indicate life-threatening. Interactions (adsbygoogle = window.adsbygoogle || []).push({});Drug-Drug
Route/DosageIV (Adults and Children): 2.5–15 mcg/kg/min; titrate to response (max dose = 40 mcg/kg/min). IV (Neonates): 2–15 mcg/kg/min. Availability (generic available)Solution for injection (requires dilution): 12.5 mg/mL Premixed infusion: 250 mg/250 mL, 500 mg/250 mL, 1000 mg/250 mL Assessment
Lab Test Considerations: Monitor potassium concentrations during therapy; may cause hypokalemia.
Toxicity and Overdose: If overdose occurs, reduction or discontinuation of therapy is the only treatment necessary because of the short duration of dobutamine. Potential Diagnoses
Implementation
IV Administration
Patient/Family Teaching
Evaluation/Desired OutcomesIncrease in cardiac output.
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