Cohen MP, Jasti K, Rye DL . Somatomedin in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1977; 45: 236–239 Show CAS PubMed Google Scholar The DCCT Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Eng J Med 1993; 329: 977–986 UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837–853 Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995; 28: 103–117 CAS PubMed Google Scholar Alder VA, Su EN, Yu DY, Cringle SJ, Yu PK . Diabetic retinopathy: early functional changes. Clin Exp Pharmol Physiol 1997; 24: 785–788 CAS Google Scholar Yoshii H, Uchino H, Ohmura C, Watanabe K, Tanaka Y, Kawamori R . Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass-spectrometry in type 2 diabetes to assess polyol pathway activity. Diabetes Res Clin Pract 2001; 51: 115–123 CAS PubMed Google Scholar Chibber R, Molinatti PA, Kohner EM . Intracellular protein glycation in cultured retinal capillary pericytes and endothelial cells exposed to high-glucose concentration. Cell Mol Biol 1999; 45: 47–57 CAS PubMed Google Scholar Gurler B, Vural H, Yilmaz N, Oguz H, Satici A, Aksoy N . The role of oxidative stress in diabetic retinopathy. Eye 2000; 14: 730–735 PubMed Google Scholar Ways DK, Sheetz MJ . The role of protein kinase C in the development of the complications of diabetes. Vitam Horm 2001; 60: 149–159 CAS Google Scholar Badr GA, Tang J, Ismail-Beigi F, Kern TS . Diabetes downregulates GLUTI expression in the retina and its microvessels but not in the cerebral cortex or its microvessels. Diabetes 2000; 49: 1016–1021 CAS PubMed Google Scholar Ban Y, Rizzolo LJ . Regulation of glucose transporters during development of the retinal pigment epithelium. Brain Res Dev Brain Res 2000; 121: 89–95 CAS PubMed Google Scholar Sone H, Deo BK, Kumagai AK . Enhancement of glucose transport by vascular endothelial growth factor in retinal endothelial cells. Invest Ophthalmol Vis Sci 2000; 41: 1876–1884 CAS PubMed Google Scholar de Abreu JR, Silva R, Cunha-Vaz JG . The blood-reinal barrier in diabetes during puberty. Arch Ophthalmol 1994; 112: 1338–1348 Google Scholar Cunha-Vaz JG, Leite E, Sousa JC, de Abreu JR . Blood-retinal barrier permeability and its relation to progression of retinopathy in patients with type 2 diabetes. A four-year follow-up study. Graefes Arch Clin Exp Ophthalmol 1993; 231: 141–145 CAS PubMed Google Scholar Alder VA, Su EN, Yu DY, Cringle S, Yu PY . Overview of studies on metabolic and vascular regulatory changes in early diabetic retinopathy. Aust NZJ Ophthalmol 1998; 26: 141–148 CAS Google Scholar Laties AM . Central retinal artery innervation. Absence of adrenergic innervation to the intraocular branches. Arch Ophthalmol 1967; 77: 405–409 CAS PubMed Google Scholar Chen YF, Oparil S . Endothelial dysfunction in the pulmonary vascular bed. Am J Med Sci 2000; 320: 223–232 CAS PubMed Google Scholar Vallance P, Collier J, Moncada S . Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989; 2: 997–1000 CAS PubMed Google Scholar Pohl U, Wagner K, de Wit C . Endothelium-derived nitric oxide in the control of tissue perfusion and oxygen supply: physiological and pathophysiological implications. Eur Heart J 1993; 14 (Suppl 1): 93–98 CAS PubMed Google Scholar Stamler JS, Loh E, Roddy MA, Currie KE, Creager MA . Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 1994; 89: 2035–2040 CAS PubMed Google Scholar Radomski MW, Palmer RM, Moncada S . Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol 1987; 92: 181–187 CAS PubMed PubMed Central Google Scholar Arndt H, Russell JB, Kurose I, Kubes P, Granger DN . Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Gastroenterology 1993; 105: 675–680 CAS PubMed Google Scholar Kubes P, Suzuki M, Granger DN . Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A 199; 88: 4651–4655 Google Scholar Bath PMW, Hassall DG, Gladwin AM, Palmer RM, Martin JF . Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro. Arterioscler Thromb 1991; 11: 254–260 CAS PubMed Google Scholar Heller R, Bussolino F, Ghigo D, Garbarino G, Pescarmona G, Till U, Bosia A . Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells. Biochem Pharmacol 1992; 44: 223–229 CAS PubMed Google Scholar Karmakar N . Interaction of transmural pressure and shear stress in the transport of albumin across the rabbit aortic wall. Atherosclerosis 2001; 156: 321–327 CAS PubMed Google Scholar Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H et al. Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice. Circ Res 2001; 89: 55–62 CAS PubMed Google Scholar Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL . Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A 1992; 89: 11059–11063 CAS PubMed PubMed Central Google Scholar Inoguchi T, Xia P, Kunisaki M, Higashi S, Feener EP, King GL . Insulin’s effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues. Am J Physiol 1994; 267: E369–E379 CAS PubMed Google Scholar Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 1996; 272: 728–731 CAS PubMed Google Scholar Giugliano D, Ceriello A, Paolisso G . Oxidative stress and diabetic vascular complications. Diabetes Care 1996; 19: 257–267 CAS PubMed Google Scholar Dunlop M . Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int 2000; 58 (Suppl 77): S3–S12 Google Scholar Stevens MJ, Dananberg J, Feldman EL, Lattimer SA, Kamijo M, Thomas TP et al. The linked roles of nitric oxide, aldose reductase and (Na+, K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat. J Clin Invest 1994; 94: 853–859 CAS PubMed PubMed Central Google Scholar Ceriello A . Hyperglycaemia: the bridge between non-enzymatic glycation and oxidative stress in the pathogenesis of diabetic complications. Diabetes Nutr Metab 1999; 12: 42–46 CAS PubMed Google Scholar Bucala R, Tracey KJ, Cerami A . Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 1991; 87: 432–438 CAS PubMed PubMed Central Google Scholar Levine L . Lactacystin stimulates arachidonic acid metabolism in rat liver cells: effects of cell density on arachidonic acid release, PGI2 production and cyclooxygenase activity. Prostag Leukotr Ess 2000; 63: 371–375 CAS Google Scholar Smith JA, Davis CL, Burgess GM . Prostaglandin E2-induced sensitization of bradykinin-evoked responses in rat dorsal root ganglion neurons is mediated by cAMP-dependent protein kinase A. Eur J Neurosci 2000; 12: 3250–3258 CAS PubMed Google Scholar Hata Y, Clermont A, Yamauchi T, Pierce EA, Suzuma I, Kagokawa H et al. Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor. J Clin Invest 2000; 106: 541–550 CAS PubMed PubMed Central Google Scholar Sato T, Sawada S, Tsuda Y, Komatsu S, Akamatsu N, Kono Y et al. The mechanism of thrombin-induced prostacyclin synthesis in human endothelial cells with reference to the gene transcription of prostacyclin-related enzymes and Ca2+ kinetics. J Pharmacol Toxicol Meth 1999; 41: 173–182 CAS Google Scholar Nagao T, Illiano S, Vanhoutte PM . Heterogeneous distribution of endothelium-dependent relaxations resistant to NG-nitro-L-arginine in rats. Am J Physiol 1992; 263: H1090–H1094 CAS PubMed Google Scholar Campbell WB, Gebremedhin D, Pratt PF, Harder DR . Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 1996; 78: 415–423 CAS PubMed Google Scholar Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Buss R . Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 1999; 401: 493–497 CAS PubMed Google Scholar Fulton D, McGiff JC, Quilley J . Pharmacological evaluation of an epoxide as the putative hyperpolarizing factor mediating the nitric oxide-independent vasodilator effect of bradykinin in the rat heart. J Pharmacol Exp Ther 1998; 287: 497–503 CAS PubMed Google Scholar Gebremedhin D, Harder DR, Pratt PF, Campbell WB . Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. J Vasc Res 1998; 35: 274–284 CAS PubMed Google Scholar Hecker M, Bara AT, Bauersachs J, Busse R . Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals. J Physiol 1994; 481: 407–414 CAS PubMed PubMed Central Google Scholar Rosolowsky M, Campbell WB . Role of PG12 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. Am J Physiol 1993; 264: H327–H335 CAS PubMed Google Scholar Matoba T, Shimokawa H, Nakashima M, Hirakawa Y, Mukai Y, Hirano K et al. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice. J Clin Invest 2000; 106: 1521–1530 CAS PubMed PubMed Central Google Scholar Knot HJ, Zimmermann PA, Nelson MT . Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels. J Physiol 1996; 492: 419–430 CAS PubMed PubMed Central Google Scholar Chaytor AT, Martin PE, Edwards DH, Griffith TM . Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery. Am J Physiol Heart Circ Physiol 2001; 280: H2441–H2450 CAS PubMed Google Scholar De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM . Endothelial dysfunction in diabetes. Br J Pharmacol 2000; 130: 963–974 CAS PubMed PubMed Central Google Scholar Kiowski W, Luscher TF, Linder L, Buhler FR . Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor. Circulation 1991; 83: 469–475 CAS PubMed Google Scholar Wang HG, Shibamoto T, Miyahara T . Endothelin-1 selectively contracts portal vein through both ETA and ETB receptors in isolated rabbit liver. Am J Physiol 1997; 273: G1036–G1043 CAS PubMed Google Scholar Ito Y, Katori M, Majima M, Kakita A . Constriction of mouse hepatic venules and sinusoids by endothelins through ETB receptor subtype. Int J Microcirc Clin Exp 1996; 16: 250–258 CAS PubMed Google Scholar Dehouck MP, Vigne P, Torpier G, Breittmayer JP, Cecchelli R, Frelin C . Endothelin-1 as a mediator of endothelial cell–pericyte interactions in bovine brain capillaries. J Cereb Blood Flow Metab 1997; 17: 464–469 CAS PubMed Google Scholar Goto K, Kasuya Y, Matsuki N, Takuwa Y, Kurihara H, Ishikawa T et al. Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle. Proc Natl Acad Sci U S A 1989; 86: 3915–3918 CAS PubMed PubMed Central Google Scholar Resink TJ, Scott-Burden T, Buhler FR . Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells. Biochem Biophys Res Commun 1989; 158: 279–286 CAS PubMed Google Scholar Hirata Y, Yoshimi H, Takata S, Watanabe TX, Kumagai S, Nakajima K, Sakakibara S . Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells. Biochem Biophys Res Commun 1988; 154: 868–875 CAS PubMed Google Scholar Chakrabarti S, Cukiernik M, Hileeto D, Evans T, Chen S . Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy. Diabetes Metab Res Rev 2000; 16: 393–407 CAS PubMed Google Scholar Abdel-Latif AA, Husain S, Yousufzai SY . Role of protein kinase C alpha and mitogen-activated activated protein kinases in endothelin-1-stimulation of cytosolic phospholipase A2 in iris sphincter smooth muscle. J Cardiovasc Pharmacol 2000; 36 (Suppl 5): S117–S119 CAS PubMed Google Scholar Husain S, Abdel-Latif AA . Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells. Biochem J 1999; 342: 87–96 CAS PubMed PubMed Central Google Scholar Li P, Ferrario CM, Brosnihan KB . Losartan inhibits thromboxane A2-induced platelet aggregation and vascular constriction in spontaneously hypertensive rats. J Cardiovasc Pharmacol 1998; 32: 198–205 CAS PubMed Google Scholar Minhas S, Eardley I, Joyce AD, Morrison JB . The effect of cyclic GMP on rabbit corporal smooth muscle tone and its modulation by cyclo-oxygenase products. Prostaglandins Leukot Essent Fatty Acids 2000; 62: 153–160 CAS PubMed Google Scholar Katusic ZS, Vanhoutte PM . Superoxide anion is an endothelium-derived contracting factor. Am J Physiol 1989; 257: H33–H37 CAS PubMed Google Scholar Bohlen HG, Lash JM . Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles. Am J Physiol 1993; 265: H219–H225 CAS PubMed Google Scholar Wen FQ, Watanabe K, Yoshida M . Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. Prostaglandins Leukot Essent Fatty Acids 1998; 59: 71–75 CAS PubMed Google Scholar Kador PF, Takahashi Y, Wyman M, Ferris F 3rd . Diabetes-like proliferative retinal changes in galactose-fed dogs. Arch Ophthalmol 1995; 113: 352–354 CAS PubMed Google Scholar Kerty E, Russell D, Bakke SJ, Nyberg-Hansen R, Rootwell K . Regional cerebral blood flow (rCBF) and cerebral vasoreactivity in patients with retinal ischaemic symptoms. J Neurol Neurosurg Psychiatry 1989; 52: 1345–1350 CAS PubMed PubMed Central Google Scholar Naruse K, Nakamura J, Hamada Y, Nakayama M, Chaya S, Komori T et al. Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes. Exp Eye Res 2000; 71: 309–315 CAS PubMed Google Scholar Iannello S, Cavaleri A, Camuto M, Belfiore F . In vitro inhibition of glucose phosphorylation by an aldose-reductase inhibitor (Tolrestat) in some non-insulin-sensitive rabbit tissues. J Diabetes Complications 1999; 13: 68–73 CAS PubMed Google Scholar Segawa M, Hirata Y, Fujimori S, Okada K . The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. Metabolism 1988; 37: 454–460 CAS PubMed Google Scholar Robison WG Jr, McBaleb ML, Feld LG, Michaelis OE, Laver N, Mercandetti M, Boninson WG . Degenerated intramural pericytes (‘ghost cells’) in the retinal capillaries of diabetic rats. Curr Eye Res 1991; 10: 339–350 PubMed Google Scholar Goldfarb S, Ziyadeh FN, Kern EF, Simmons DA . Effects of polyol-pathway inhibition and dietary myo-inositol on glomerular hemodynamic function in experimental diabetes mellitus in rats. Diabetes 1991; 40: 465–471 CAS PubMed Google Scholar Narayanan S . Aldose reductase and its inhibition in the control of diabetic complications. Ann Clin Lab Sci 1993; 23: 148–158 CAS PubMed Google Scholar Stevens MJ, Henry DN, Thomas TP, Killen PD, Greene DA . Aldose reductase gene expression and osmotic dysregulation in cultured human retinal pigment epithelial cells. Am J Physiol 1993; 265: E428–E438 CAS PubMed Google Scholar Lim SS, Jung SH, Ji J, Shin KH, Keum SR . Synthesis of flavenoids and their effects on aldose reductase and and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. J Pharm Pharmacol 2001; 53: 653–668 CAS PubMed Google Scholar Sato S, Secchi EF, Lizak MJ, Fukase S, Ohta N, Murata M et al. Polyol formation and NADPH-dependent reductases in dog retinal capillary pericytes and endothelial cells. Invest Ophthalmol Vis Sci 1999; 40: 697–704 CAS PubMed Google Scholar Bravi MC, Pietrangeli P, Laurenti O, Basili S, Cassone-Faldetta M, Ferri C, De Mattia G . Polyol pathway activation and glutathione redox status in non-insulin-dependent diabetic patients. Metabolism 1997; 46: 1194–1198 CAS PubMed Google Scholar Kishi Y, Schmelzer JD, Yao JK, Zollman PJ, Nickander KK, Tritschler HJ, Low PA . Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy. Diabetes 1999; 48: 2045–2051 CAS PubMed Google Scholar Dunn JA, McCance DR, Thorpe SR, Lyons TJ, Baynes JW . Age-dependent accumulation of N epsilon-(carboxymethyl)lysine and N epsilon-(carboxymethyl)hydroxylysine in human skin collagen. Biochemistry 1991; 30: 1205–1210 CAS PubMed Google Scholar Khalifah RG, Baynes JW, Hudson BG . Amadorins: novel post-Amadori inhibitors of advanced glycation reactions. Biochem Biophys Res Commun 1999; 257: 251–258 CAS PubMed Google Scholar Stitt AW . Advanced glycation: an important pathological event in diabetic and age related ocular disease. Br J Ophthalmol 2001; 85: 746–753 CAS PubMed PubMed Central Google Scholar Gurler B, Vural H, Yilmaz N, Oguz H, Satici A, Aksoy N . The role of oxidative stress in diabetic retinopathy. Eye 2000; 14: 730–735 PubMed Google Scholar Agardh E, Hultberg B, Agardh C . Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats. Curr Eye Res 2000; 21: 543–549 CAS PubMed Google Scholar Kern TS, Kowluru RA, Engerman RL . Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione. Invest Ophthalmol Vis Sci 1994; 35: 2962–2967 CAS PubMed Google Scholar Roginsky V, Barsukova T . Superoxide dismutase inhibits lipid peroxidation in micelles. Chem Phys Lipids 2001; 111: 87–91 CAS PubMed Google Scholar Sozmen EY, Sozmen B, Delen Y, Onat T . Catalase/superoxide dismutase (sod) and catalase/paraoxonase (pon) ratios may implicate poor glycemic control. Arch Med Res 2001; 32: 283–287 CAS PubMed Google Scholar Mates JM, Perez-Gomez C, Nunez de Castro I . Antioxidant enzymes and human diseases. Clin Biochem 1999; 32: 595–603 CAS PubMed Google Scholar Agardh CD, Agardh E, Hultberg B, Qian Y, Ostenson CG . The glutathione levels are reduced in Goto-Kakizaki rat retina, but are not influenced by aminoguanidine treatment. Curr Eye Res 1998; 17: 251–256 CAS PubMed Google Scholar Kowluru RN, Keern TS, Engerman RL . Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system. Free Radic Biol Med 1997; 22: 587–592 CAS PubMed Google Scholar Nourooz-Zadeh J, Pereira P . F(2) isoprostanes, potential specific markers of oxidative damage in human retina. Ophthalmic Res 2000; 32: 133–137 CAS PubMed Google Scholar Bohlen HG, Lash JM . Topical hyperglycemia rapidly suppresses EDRG-mediated vasodilation of normal rat arterioles. Am J Physiol 1993; 265: H210–H225 Google Scholar Haefliger IO, Flammer J, Beny JL, Luscher TF . Endothelium-dependent vasoactive modulation in the ophthalmic circulation. Prog Retin Eye Res 2001; 20: 209–225 CAS PubMed Google Scholar Moller P, Loft S, Lundby C, Olsen NV . Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans. FASEB J 2001; 15: 1181–1186 CAS PubMed Google Scholar Hinokio Y, Suzuki S, Hirai M, Chiba M, Hirai A, Toyota T . Oxidative DNA damage in diabetes mellitus: its association with diabetic complications. Diabetologia 1999; 42: 995–998 CAS PubMed Google Scholar Li W, Yanoff M, Jian B, He Z . Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas. Cell Mol Biol 1999; 45: 59–66 CAS PubMed Google Scholar Podesta F, Romeo G, Liu WH, Krajewski S, Reed JC, Gerhardinger C, Lorenzi M . Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro. Am J Pathol 2000; 156: 1025–1032 CAS PubMed PubMed Central Google Scholar Li W, Yanoff M, Liu X, Ye X . Retinal capillary pericyte apoptosis in early human diabetic retinopathy. Chin Med J (Engl) 1997; 110: 659–663 CAS Google Scholar Kern TS, Engerman RL . Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia. Arch Ophthalmol 1996; 114: 306–310 CAS PubMed Google Scholar Kern TS, Engerman RL . Vascular lesions in diabetes are distributed non-uniformly within the retina. Exp Eye Res 1995; 60: 545–549 CAS PubMed Google Scholar Stitt AW, Gardiner TA, Archer DB . Histological and ultrastructural investigation of retinal microaneurysm development in diabetic patients. Br J Ophthalmol 1995; 79: 362–367 CAS PubMed PubMed Central Google Scholar Nishikawa T, Giardino I, Edelstein D, Brownlee M . Changes in diabetic retinal matrix protein mRNA levels in common transgenic mouse strain. Curr Eye Res 2000; 21: 581–587 CAS PubMed Google Scholar Bek T, Ledet T . Glycoprotein deposition in vascular walls of diabetic retinopathy. A histopathological and immunohistochemical study. Acta Ophthalmol Scand 1996; 74: 385–390 CAS PubMed Google Scholar Jerdan JA, Michels RG, Glaser BM . Diabetic preretinal membranes. An immunohisochemical study. Arch Opthalmol 1986; 104: 286–290 CAS Google Scholar Casaroli Marano RP, Preissner KT, Vilaro S . Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy. Exp Eye Res 1995; 60: 5–17 CAS PubMed Google Scholar Roy S, Lorenzi M . Early biosynthetic changes in the diabetic-like retinopathy of galactose-fed rats. Diabetologia 1996; 39: 735–738 CAS PubMed Google Scholar Hosoda Y, Okada M, Matsumura M, Ogino N, Honda Y, Nagai Y . Epiretinal membrane of proliferative diabetic retinopathy: an immunohistochemical study. Ophthalmic Res 1993; 25: 289–294 CAS PubMed Google Scholar Abrass CK, Peterson CV, Raugi GJ . Phenotypic expression of collagen types in mesangial matrix of diabetic and nondiabetic rats. Diabetes 1988; 37: 1695–1702 CAS PubMed Google Scholar Spirin KS, Saghizadeh M, Lewin SL, Zardi L, Kenney MC, Ljubimov AV . Basement membrane and growth factor gene expression in normal and diabetic human retinas. Curr Eye Res 1999; 18: 490–499 CAS PubMed Google Scholar Jian B, Jones PL, Li Q, Mohler ER 3rd, Schoen FJ, Levy RJ . Matrix metalloproteinase-2 is associated with tenascin-c in calcific aortic stenosis. Am J Pathol 2001; 159: 321–327 CAS PubMed PubMed Central Google Scholar Boeri D, Maiello M, Lorenzi M . Increased prevalence of microthromboses in retinal capillaries of diabetic individuals. Diabetes 2000; 50: 1432–1439 Google Scholar Lee IK, Koya D, Ishi H, Kanoh H, King GL . d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cells by an increase of DAG kinase activity. Diabetes Res Clin Pract 1999; 45: 183–190 CAS PubMed Google Scholar Takahashi T, Hato F, Yamane T, Fukumasu H, Suzuki K, Ogita S et al. Activation of human neutrophils by cytokine-activated endothelial cells. Circ Res 2001; 88: 422–429 CAS PubMed Google Scholar de la Cruz JP, Moreno A, Ruiz-Ruiz MI, Garcia-Campos J, Sanchez de la Cuesta F . Effect of WEB 2086-BS, an antagonist of platelet-activating factor receptors, on retinal vascularity in diabetic rats. Eur J Pharmacol 1998; 360: 37–42 CAS PubMed Google Scholar Bussolino F, Gremo F, Tetta C, Pescarmona GP, Camussi G . Production of platelet-activating factor by chick retina. J Biol Chem 1986; 261: 16502–16508 CAS PubMed Google Scholar Thierry A, Doly M, Braquet P, Cluzel J, Meyniel G . Presence of specific platelet-activating factor binding sites in the rat retina. Eur J Pharmacol 1989; 163: 97–101 CAS PubMed Google Scholar Omoto S, Nomura S, Shouzu A, Hayakawa T, Shimizu H, Miyake Y et al. Significance of platelet-derived microparticles and activated platelets in diabetic nephropathy. Nephron 1999; 81: 271–277 CAS PubMed Google Scholar Nomura S, Nakamura T, Cone J, Tandon NN, Kambayashi J . Cytometric analysis of high shear-induced platelet microparticles and effect of cytokines on microparticle generation. Cytometry 2000; 40: 173–181 CAS PubMed Google Scholar Li M, Goto S, Sakai H, Kim JY, Ichikawa N, Yoshida M et al. Enhanced shear-induced von Willebrand factor binding to platelets in acute myocardial infarction. Thromb Res 2000; 100: 251–261 CAS PubMed Google Scholar De la Cruz JP, Maximo MA, Blanco E, Moreno A, Sanchez de la Cuesta F . Effect of erythrocytes and prostacyclin production in the effect of fructose and sorbitol on platelet activation in human whole blood in vitro. Thromb Res 1997; 86: 515–524 CAS PubMed Google Scholar Phillips AO, Morrisey K, Steadman R, Williams JD . Decreased degradation of collagen and fibronectin following exposure of proximal cells to glucose. Exp Nephrol 1999; 7: 449–462 CAS PubMed Google Scholar De La Cruz JP, Moreno A, Ruiz-Ruiz MI, Garcia Campos J, Sanchez de la Cuesta F . Effect of camonagrel, a selective thromboxane synthase inhibitor, on retinal vascularization in experimental diabetes. Eur J Pharmacol 1998; 350: 81–85 CAS PubMed Google Scholar Haimovich B, Lipfert L, Brugge JS, Shattil SJ . Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem 1993; 268: 15868–15877 CAS PubMed Google Scholar Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci U S A 1999; 96: 10836–10841 CAS PubMed PubMed Central Google Scholar Hayashi M, Imai Y, Oh-ishi S . Phorbol ester stimulates PAF synthesis via the activation of protein kinase C in rat leukocytes. Lipids 1991; 26: 1054–1059 CAS PubMed Google Scholar Whatley RE, Nelson P, Zimmerman GA, Stevens DL, Parker CJ, McIntyre TM, Prescott SM . The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C. J Biol Chem 1989; 264: 6325–6333 CAS PubMed Google Scholar Okayama N, Coe L, Itoh M, Alexander JS . Exogenous nitric oxide increases neutrophil adhesion to cultured human endothelial monolayers through a protein kinase G dependent mechanism. Inflammation 1999; 23: 37–50 CAS PubMed Google Scholar Triggiani M, Oriente A, Golino P, Gentile M, Battaglia C, Brevetti G, Marone G . Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. Biochem Pharmacol 1999; 58: 1341–1348 CAS PubMed Google Scholar Komatsu H, Amano M, Yamaguchi S, Sugahara K . Inhibition of activation of human peripheral blood eosinophils by Y-24180, an antagonist to platelet-activating factor receptor. Life Sci 1999; 65: PL171–PL176 CAS PubMed Google Scholar Kubes P, Grisham MB, Barrowman JA, Gaginella T, Granger DN . Leukocyte-induced vascular protein leakage in cat mesentery. Am J Physiol 1991; 261: H1872–H1879 CAS PubMed Google Scholar Zimmerman GA, McIntyre TM, Prescott SM . Thrombin stimulates the adherence of neutrophils to human endothelial cell in vitro. Immunol Today 1992; 13: 93–99 CAS PubMed Google Scholar Granger DN, Kubes P . The microcirculation and inflammation: modulation of leukocyte-enothelial cell adhesion. J Leukoc Biol 1994; 55: 662–675 CAS PubMed Google Scholar Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP . Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol 2001; 158: 147–152 CAS PubMed PubMed Central Google Scholar Lane TA, Lamkin GE, Wancewicz E . Modulation of endothelial cell expression of intercellular adhesion molecule 1 by protein kinase C activation. Biochem Biophys Res Commun 1989; 161: 945–952 CAS PubMed Google Scholar Wertheimer SJ, Myers CL, Wallace RW, Parks TP . Intercellular adhesion molecule-1 gene expression in human endothelial cells. Differential regulation by tumor necrosis factor-alpha and phorbol myristate acetate. J Biol Chem 1992; 267: 12030–12035 CAS PubMed Google Scholar Arndt H, Russell JB, Kurose I, Kubes P, Granger DN . Mediators of leukocyte adhesion in rat mesenteric venules elicited by inhibition of nitric oxide synthesis. Gastroenterology 1993; 105: 675–680 CAS PubMed Google Scholar Kubes P, Suzuki M, Granger DN . Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991; 88: 4651–4655 CAS PubMed PubMed Central Google Scholar Worthen GS, Schwab B 3rd, Elson EL, Downey GP . Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries. Science 1989; 245: 183–186 CAS PubMed Google Scholar Kinukawa Y, Shimura M, Tamai M . Quantifying leukocyte dynamics and plugging in retinal microcirculation of streptozotosin-induced diabetic rats. Curr Eye Res 1999; 18: 49–55 CAS PubMed Google Scholar Meisel SR, Shapiro H, Radnay J, Neuman Y, Khaskia AR, Gruener N et al. Increased expression of neutrophil and monocyte adhesion molecules LFA-1 and Mac-1 and their ligand ICAM-1 and VLA-4 throughout the acute phase of myocardial infarction: possible implications for leukocyte aggregation and microvascular plugging. J Am Coll Cardiol 1998; 31: 120–125 CAS PubMed Google Scholar Schroder S, Palinski W, Schmid-Schonbein GW . Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. Am J Pathol 1991; 139: 81–100 CAS PubMed PubMed Central Google Scholar Wallow IH, Danis RP, Bindley C, Neider M . Cystoid macular degeneration in experimental branch retinal vein occlusion. Ophthalmology 1988; 95: 1371–1379 CAS PubMed Google Scholar Bellhorn RW, Burns MS, Benjamin JV . Retinal vessel abnormalities of phototoxic retinopathy in rats. Invest Ophthalmol Vis Sci 1980; 19: 584–595 CAS PubMed Google Scholar Lu M, Kuroki M, Amano S, Tolentino M, Keough K, Kim I et al. Advanced glycation end products increase retinal vascular endothelial growth factor expression. J Clin Invest 1998; 101: 1219–1224 CAS PubMed PubMed Central Google Scholar Gries FA . Alternative therapeutic principles in the prevention of microvascular and neuropathic complications. Diabetes Res Clin Pract 1995; 28 (Suppl): S201–S207 CAS PubMed Google Scholar Michiels C, Arnould T, Remacle J . Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions. Biochim Biophys Acta 2000; 1497: 1–10 CAS PubMed Google Scholar Tailor A, Granger DN . Role of adhesion molecules in vascular regulation and damage. Curr Hypertens Rep 2000; 2: 78–83 CAS PubMed Google Scholar Sivalingam A, Kenney J, Brown GC, Benson WE, Donoso L . Basic fibroblast growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch Ophthalmol 1990; 108: 869–872 CAS PubMed Google Scholar Michaelson I . The mode of development of the vascular system of the retina with observations on its significance for certain retinal diseases. Trans Ophthalmol Soc UK 1948; 68: 137–180 Google Scholar Ashton N . Retinal vascularization in health and disease. Am J Ophthalmol 1957; 44: 7–17 CAS PubMed Google Scholar Lahrmann C, Bek T . Foveal haemorrhages in diabetic retinopathy. Clinical characteristics and visual outcome. Acta Ophthalmol Scand 2000; 78: 169–172 CAS PubMed Google Scholar Garner A . Histopathology of diabetic retinopathy in man. Eye 1993; 7: 250–253 PubMed Google Scholar Stefansson E . Laser treatment in diabetes-related eye complications. Nord Med 1992; 107: 309–310 CAS PubMed Google Scholar Scott IU, Flynn HW Jr, Hughes JR . Echographic evaluation of a patient with diabetes and dense vitreous hemorrhage: an avulsed retinal vessel may mimic a tractional retinal detachment. Am J Ophthalmol 2001; 131: 515–516 CAS PubMed Google Scholar Zhu H, Bunn HF . Oxygen sensing and signaling: impact on the regulation of physiologically important genes. Respir Physiol 1999; 115: 239–247 CAS PubMed PubMed Central Google Scholar Zhu H, Riggs AF . Yeast flavohemoglobin is an ancient protein related to globins and a reductase family. Proc Natl Acad Sci U S A 1992; 89: 5015–5019 CAS PubMed PubMed Central Google Scholar Caro J . Hypoxia regulation of gene transcription. High Alt Med Biol 2001; 2: 145–154 CAS PubMed Google Scholar Zhong H, Hanrahan C, van der Poel H, Simons JW . Hypoxia-inducible factor 1 alpha and 1 beta proteins share common signaling pathways in human prostate cancer cells. Biochem Biophys Res Commun 2001; 284: 352–356 CAS PubMed Google Scholar Mazure NM, Chen EY, Laderoute KR, Giaccia AJ . Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 1997; 90: 3322–3331 CAS PubMed Google Scholar Ozaki H, Yu AY, Della N, Ozaki K, Luna JD, Yamada H et al. Hypoxia inducible factor-1 alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci 1999; 40: 182–189 CAS PubMed Google Scholar Ferrara N, Henzel WJ . Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161: 851–858 CAS PubMed Google Scholar Levy AP, Levy NS, Wegner S, Goldberg MA . Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 1995; 270: 13333–13340 CAS PubMed Google Scholar Williams B . Vascular permeability/vascular endothelial growth factors: a potential role in the pathogenesis and treatment of vascular diseases. Vasc Med 1996; 1: 251–258 CAS PubMed Google Scholar Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331: 1480–1487 CAS PubMed Google Scholar Ferrara N . Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 1999; 56: 794–814 CAS PubMed Google Scholar Mesri M, Morales-Ruiz M, Ackermann EJ, Bennett CF, Pober JS, Sessa WC, Altieri DC . Suppression of vascular endothelial growth factor-mediated endothelial cell protection by surviving targeting. Am J Pathol 2001; 158: 1757–1765 CAS PubMed PubMed Central Google Scholar de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT . The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 1992; 255: 989–991 CAS PubMed Google Scholar Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P . Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 1992; 187: 1579–1586 CAS PubMed Google Scholar Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M . Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 1990; 5: 519–524 CAS PubMed Google Scholar Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB . Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene 1991; 6: 1677–1683 CAS PubMed Google Scholar Matthews W, Jordan CT, Gavin M, Jenkins NA, Copeland NG, Lemischka IR . A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci U S A 1991; 88: 9026–9030 CAS PubMed PubMed Central Google Scholar Quinn TP, Peters KG, De Vries C, Ferrara N, Williams LT . Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci U S A 1993; 90: 7533–7537 CAS PubMed PubMed Central Google Scholar Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A . High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993; 72: 835–846 CAS PubMed Google Scholar Takahashi T, Yamaguchi S, Chida K, Shibuya M . A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J 2001; 20: 2768–2778 CAS PubMed PubMed Central Google Scholar Takahashi T, Shibuya M . The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 1997; 14: 2079–2089 CAS PubMed Google Scholar Qi JH, Claesson-Welsh L . VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Exp Cell Res 2001; 263: 173–182 CAS PubMed Google Scholar Suzuma K, Naruse K, Suzuma I, Takahara N, Ueki K, Aiello LP, King GL . Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells. J Biol Chem 2000; 275: 40725–40731 CAS PubMed Google Scholar Enaida H, Kabuyama Y, Oshima Y, Sakamoto T, Kato K, Kochi H, Homma Y . VEGF-dependent signaling in retinal microvascular endothelial cells. Fukushima J Med Sci 1999; 45: 77–91 CAS PubMed Google Scholar Igal RA, Caviglia JM, de Gomez Dumm IN, Coleman RA . Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis. J Lipid Res 2001; 42: 88–95 CAS PubMed Google Scholar Kim MJ, Kim E, Ryu SH, Suh PG . The mechanism of phospholipase C-gamma1 regulation. Exp Mol Med 2000; 32: 101–109 CAS PubMed Google Scholar Boulton M, Foreman D, Williams G, McLeod D . VEGF localisation in diabetic retinopathy. Br J Ophthalmol 1998; 82: 561–568 CAS PubMed PubMed Central Google Scholar Adamis AP, Miller JW, Bernal MT, D’Amico DJ, Folkman J, Yeo TK, Yeo KT . Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994; 118: 445–450 CAS PubMed Google Scholar Malecaze F, Clamens S, Simorre-Pinatel V, Mathis A, Chollet P, Favard C et al. Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy. Arch Ophthalmol 1994; 112: 1476–1482 CAS PubMed Google Scholar Segawa Y, Shirao Y, Yamagishi S, Higashide T, Kobayashi M, Katsuno K et al. Upregulation of retinal vascular endothelial growth factor mRNAs in spontaneously diabetic rats without ophthalmoscopic retinopathy. A possible participation of advanced glycation end products in the development of the early phase of diabetic retinopathy. Ophthalmic Res 1998; 30: 333–339 CAS PubMed Google Scholar Simpson DA, Murphy GM, Bhaduri T, Gardiner TA, Archer DB, Stitt AW . Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia. Biochem Biophys Res Commun 1999; 262: 333–340 CAS PubMed Google Scholar Grishko V, Solomon M, Breit JF, Killilea DW, Ledoux SP, Wilson GL, Gillespie MN . Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene. FASEB J 2001; 15: 1267–1269 CAS PubMed Google Scholar Smith G, McLeod D, Foreman D, Boulton M . Immunolocalisation of the VEGF receptors FLT-1, KDR, and FLT-4 in diabetic retinopathy. Br J Ophthalmol 1999; 83: 486–494 CAS PubMed PubMed Central Google Scholar Gilbert RE, Vranes D, Berka JL, Kelly DJ, Cox A, Wu LL et al. Vascular endothelial growth factor and its receptors in control and diabetic rat eyes. Lab Invest 1998; 78: 1017–1027 CAS PubMed Google Scholar Amin RH, Frank RN, Kennedy A, Eliott D, Puklin JE, Abrams GW . Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 1997; 38: 36–47 CAS PubMed Google Scholar Sone H, Kawakami Y, Okuda Y, Sekine Y, Honmura S, Matsuo K et al. Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes. Diabetologia 1997; 40: 726–730 CAS PubMed Google Scholar Clermont AC, Aiello LP, Mori F, Aiello LM, Bursell SE . Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy. Am J Ophthalmol 1997; 124: 433–446 CAS PubMed Google Scholar Tolentino MJ, Miller JW, Gragoudas ES, Jakobiec FA, Flynn E, Chatzistefanou K et al. Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate. Ophthalmology 1996; 103: 1820–1828 CAS PubMed Google Scholar Kevil CG, Payne DK, Mire E, Alexander JS . Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins. J Biol Chem 1998; 273: 15099–15103 CAS PubMed Google Scholar Esser S, Lampugnani MG, Corada M, Dejana E, Risau W . Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 1998; 111: 1853–1865 CAS PubMed Google Scholar Yoshida A, Feke GT, Morales-Stoppello J, Collas GD, Goger DG, McMeel JW . Retinal blood flow alterations during progression of diabetic retinopathy. Arch Ophthalmol 1983; 101: 225–227 CAS PubMed Google Scholar Robinson GS, Pierce EA, Rook SL, Foley E, Webb R, Smith LE . Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci U S A 1996; 93: 4851–4856 CAS PubMed PubMed Central Google Scholar Adamis AP, Shima DT, Tolentino MJ, Gragoudas ES, Ferrara N, Folkman J et al. Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol 1996; 114: 66–71 CAS PubMed Google Scholar Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, Riddle L et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A 1995; 92: 10457–10461 CAS PubMed PubMed Central Google Scholar Poulsen JE . Recovery from retinopathy in a case of diabetes with Simmond’s disease. Diabetes 1953; 2: 7–12 CAS PubMed Google Scholar Smith LE, Kopchick JJ, Chen W, Knapp J, Kinose F, Daley D et al. Essential role of growth hormone in ischemia-induced retinal neovascularization. Science 1997; 276: 1706–1709 CAS PubMed Google Scholar Hyer SL, Sharp PS, Brooks RA, Burrin JM, Kohner EM . A two-year follow-up study of serum insulinlike growth factor-I in diabetics with retinopathy. Metabolism 1989; 38: 586–589 CAS PubMed Google Scholar Hyer SL, Sharp PS, Brooks RA, Burrin JM, Kohner EM . Serum IGF-1 concentration in diabetic retinopathy. Diabet Med 1988; 5: 356–360 CAS PubMed Google Scholar Grant MB, Mames RN, Fitzgerald C, Ellis EA, Aboufriekha M, Guy J . Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor. Diabetologia 1993; 36: 282–291 CAS PubMed Google Scholar Lee HC, Lee KW, Chung CH, Chung YS, Lee EJ, Lim SK et al. IGF-I of serum and vitreous fluid in patients with diabetic proliferative retinopathy. Diabetes Res Clin Pract 1994; 24: 85–88 CAS PubMed Google Scholar Nakao-Hayashi J, Ito H, Kanayasu T, Morita I, Murota S . Stimulatory effects of insulin and insulin-like growth factor I on migration and tube formation by vascular endothelial cells. Atherosclerosis 1992; 92: 141–149 CAS PubMed Google Scholar King GL, Goodman AD, Buzney S, Moses A, Kahn CR . Receptors and growth promoting effects of insulin and insulin-like growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest 1985; 75: 1028–1036 CAS PubMed PubMed Central Google Scholar Nicosia RF, Nicosia SV, Smith M . Vascular endothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. Am J Pathol 1994; 145: 1023–1029 CAS PubMed PubMed Central Google Scholar Grant MB, Mames RN, Fitzgerald C, Ellis EA, Aboufriekha M, Guy J . Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor. Diabetologia 1993; 36: 282–291 CAS PubMed Google Scholar Boney CM, Sekimoto H, Gruppuso PA, Frackelton AR Jr . Src family tyrosine kinases participate in insulin-like growth factor in mitogenic signaling in 3t3-11 cells. Cell Growth Differ 2001; 12: 379–386 CAS PubMed Google Scholar Shoba LN, Newman M, Liu W, Lowe WL Jr . LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes. Endocrinology 2001; 142: 3980–3986 CAS PubMed Google Scholar Yamada M, Tanabe K, Wada K, Shimoke K, Ishikawa Y, Ikeuchi T et al. Differences in survival-promoting effects and intracellular signaling properties of BDNF and IGF-1 in cultured cerebral cortical neurons. J Neurochem 2001; 78: 940–951 CAS PubMed Google Scholar Arsenijevic Y, Weiss S, Schneider B, Aebischer P . Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2. J Neurosci 2001; 21: 7194–7202 CAS PubMed PubMed Central Google Scholar Burren CP, Berka JL, Edmondson SR, Werther GA, Batch JA . Localization of mRNAs for insulin-like growth factor-I (IGF-I), IGF-I receptor, and IGF binding proteins in rat eye. Invest Ophthalmol Vis Sci 1996; 37: 1459–1468 CAS PubMed Google Scholar Tollefsen SE, Heath-Monnig E, Cascieri MA, Bayne ML, Daughaday WH . Endogenous insulin-like growth factor (IGF) binding proteins cause IGF-1 resistance in cultured fibroblasts from a patient with short stature. J Clin Invest 1991; 87: 1241–1250 CAS PubMed PubMed Central Google Scholar Meyer-Schwickerath R, Pfeiffer A, Blum WF, Freyberger H, Klein M, Losche C et al. Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. J Clin Invest 1993; 92: 2620–2625 CAS PubMed PubMed Central Google Scholar Boulton M, Gregor Z, McLeod D, Charteris D, Jarvis-Evans J, Moriarty P et al. Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management. Br J Ophthalmol 1997; 81: 228–233 CAS PubMed PubMed Central Google Scholar Burgos R, Mateo C, Canton A, Hernandez C, Mesa J, Simo R . Vitreous levels of IGF-I, IGF binding protein 1, and IGF binding protein 3 in proliferative diabetic retinopathy: a case-control study. Diabetes Care 2000; 23: 80–83 CAS PubMed Google Scholar Spoerri PE, Ellis EA, Tarnuzzer RW, Grant MB . Insulin-like growth factor: receptor and binding proteins in human retinal endothelial cell cultures of diabetic and non-diabetic origin. Growth Horm IGF Res 1998; 8: 125–132 CAS PubMed Google Scholar Tucci M, Nygard K, Tanswell BV, Farber HW, Hill DJ, Han VK . Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells. J Endocrinol 1998; 157: 13–24 CAS PubMed Google Scholar Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, Suen LF et al. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc Natl Acad Sci USA 1998; 95: 10188–10193 CAS PubMed PubMed Central Google Scholar Moriarty P, Boulton M, Dickson A, McLeod D . Production of IGF-I and IGF binding proteins by retinal cells in vitro. Br J Ophthalmol 1994; 78: 638–642 CAS PubMed PubMed Central Google Scholar Presta M, Maier JA, Rusnati M, Ragnotti G . Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active form. J Cell Physiol 1989; 140: 68–74 CAS PubMed Google Scholar Globus RK, Plouet J, Gospodarowicz D . Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix. Endocrinology 1989; 124: 1539–1547 CAS PubMed Google Scholar Bashkin P, Doctrow S, Klagsbrun M, Svahn CM, Folkman J, Vlodavsky I . Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry 1989; 28: 1737–1743 CAS PubMed Google Scholar Stavri GT, Zachary IC, Baskerville PA, Martin JF, Erusalimsky JD . Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Synergistic interaction with hypoxia. Circulation 1995; 92: 11–4 CAS PubMed Google Scholar Ozaki H, Okamoto N, Ortega S, Chang M, Ozaki K, Sadda S et al. Basic fibroblast growth factor is neither necessary nor sufficient for the development of retinal neovascularization. Am J Pathol 1998; 153: 757–765 CAS PubMed PubMed Central Google Scholar Seghezzi G, Patel S, Ren CJ, Gualandris A, Pintucci G, Robbins ES et al. Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol 1998; 141: 1659–1673 CAS PubMed PubMed Central Google Scholar Williams LT . Signal transduction by the platelet-derived growth factor receptor. Science 1989; 243: 1564–1570 CAS PubMed Google Scholar Claesson-Welsh L . Platelet-derived growth factor receptor signals. J Biol Chem 1994; 269: 32023–32026 CAS PubMed Google Scholar Kourembanas S, Hannan RL, Faller DV . Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J Clin Invest 1990; 86: 670–674 CAS PubMed PubMed Central Google Scholar Kuwabara K, Ogawa S, Matsumoto M, Koga S, Clauss M, Pinsky DJ et al. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl Acad Sci USA 1995; 92: 4606–4610 CAS PubMed PubMed Central Google Scholar Freyberger H, Brocker M, Yakut H, Hammer J, Effert R, Schifferdecker E et al. Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy. Exp Clin Endocrinol Diabetes 2000; 108: 106–109 CAS PubMed Google Scholar Koyama N, Watanabe S, Tezuka M, Morisaki N, Saito Y, Yoshida S . Migratory and proliferative effect of platelet-derived growth factor in rabbit retinal endothelial cells: evidence of an autocrine pathway of platelet-derived growth factor. J Cell Physiol 1994; 158: 1–6 CAS PubMed Google Scholar Smits A, Hermansson M, Nister M, Karnushina I, Heldin CH, Westermark B, Funa K . Rat brain capillary endothelial cells express functional PDGF B-type receptors. Growth Factors 1989; 2: 1–8 CAS PubMed Google Scholar Battegay EJ, Rupp J, Iruela-Arispe L, Sage EH, Pech M . PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. J Cell Biol 1994; 125: 917–928 CAS PubMed Google Scholar Forsberg K, Valyi-Nagy I, Heldin CH, Herlyn M, Westermark B . Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc Natl Acad Sci USA 1993; 90: 393–397 CAS PubMed PubMed Central Google Scholar Laterra J, Nam M, Rosen E, Rao JS, Lamszus K, Goldberg ID, Johnston P . Scatter factor/hepatocyte growth factor gene transfer enhances glioma growth and angiogenesis in vivo. Lab Invest 1997; 76: 565–577 CAS PubMed Google Scholar Shinozuka H, Kubo Y, Katyal SL, Coni P, Ledda-Columbano GM, Columbano A, Nakamura T . Roles of growth factors and of tumor necrosis factor-alpha on liver cell proliferation induced in rats by lead nitrate. Lab Invest 1994; 71: 35–41 CAS PubMed Google Scholar Pons E, Uphoff CC, Drexler HG . Expression of hepatocyte growth factor and its receptor c-met in human leukemia-lymphoma cell lines. Leuk Res 1998; 22: 797–804 CAS PubMed Google Scholar He PM, He S, Garner JA, Ryan SJ, Hinton DR . Retinal pigment epithelial cells secrete and respond to hepatocyte growth factor. Biochem Biophys Res Commun 1998; 249: 253–257 CAS PubMed Google Scholar Cai W, Rook SL, Jiang ZY, Takahara N, Aiello LP . Mechanisms of hepatocyte growth factor-induced retinal endothelial cell migration and growth. Invest Ophthalmol Vis Sci 2000; 41: 1885–1893 CAS PubMed Google Scholar Grant DS, Kleinman HK, Goldberg ID, Bhargava MM, Nickoloff BJ, Kinsella JL et al. Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci USA 1993; 90: 1937–1941 CAS PubMed PubMed Central Google Scholar Lamszus K, Schmidt NO, Jin L, Laterra J, Zagzag D, Way D et al. Scatter factor promotes motility of human glioma and neuromicrovascular endothelial cells. Int J Cancer 1998; 75: 19–28 CAS PubMed Google Scholar Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA . Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991; 251: 802–804 CAS PubMed Google Scholar Shiota G, Kawasaki H, Nakamura T, Schmidt EV . Inhibitory effect of hepatocyte growth factor against FaO hepatocellular carcinoma cells may be associated with changes of intracellular signalling pathways mediated by protein kinase C. Res Commun Mol Pathol Pharmacol 1994; 85: 271–278 CAS PubMed Google Scholar Graziani A, Gramaglia D, Cantley LC, Comoglio PM . The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem 1991; 266: 22087–22090 CAS PubMed Google Scholar Derman MP, Cunha MJ, Barros EJ, Nigam SK, Cantley LG . HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase. Am J Physiol 1995; 268: F1211–F1217 CAS PubMed Google Scholar Morishita R, Nakamura S, Nakamura Y, Aoki M, Moriguchi A, Kida I et al. Potential role of an endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes. Diabetes 1997; 46: 138–142 CAS PubMed Google Scholar Van Belle E, Witzenbichler B, Chen D, Silver M, Chang L, Schwall R, Isner JM . Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis. Circulation 1998; 97: 381–390 CAS PubMed Google Scholar Wojta J, Kaun C, Breuss JM, Koshelnick Y, Beckmann R, Hattey E et al. Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells. Lab Invest 1999; 79: 427–438 CAS PubMed Google Scholar Gille J, Khalik M, Konig V, Kaufmann R . Hepatocyte growth factor/scatter factor (HGF/SF) induces vascular permeability factor (VPF/VEGF) expression by cultured keratinocytes. J Invest Dermatol 1998; 111: 1160–1165 CAS PubMed Google Scholar Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG . Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc Natl Acad Sci USA 1991; 88: 9267–9271 CAS PubMed PubMed Central Google Scholar Terman B, Khandke L, Dougher-Vermazan M, Maglione D, Lassam NJ, Gospodarowicz D et al. VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor. Growth Factors 1994; 11: 187–195 CAS PubMed Google Scholar Landgren E, Schiller P, Cao Y, Claesson-Welsh L . Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1. Oncogene 1998; 16: 359–367 CAS PubMed Google Scholar Seetharam L, Gotoh N, Maru Y, Neufeld G, Yamaguchi S, Shibuya M . A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene 1995; 10: 135–147 CAS PubMed Google Scholar Ziche M, Maglione D, Ribatti D, Morbidelli L, Lago CT, Battisti M et al. Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic. Lab Invest 1997; 76: 517–531 CAS PubMed Google Scholar Cao Y, Chen H, Zhou L, Chiang MK, Anand-Apte B, Weatherbee JA et al. Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR. J Biol Chem 1996; 271: 3154–3162 CAS PubMed Google Scholar Yamashita H, Eguchi S, Watanabe K, Takeuchi S, Yamashita T, Miura M . Expression of placenta growth factor (PIGF) in ischaemic retinal diseases. Eye 1999; 13: 372–374 PubMed Google Scholar Khaliq A, Foreman D, Ahmed A, Weich H, Gregor Z, McLeod D, Boulton M . Increased expression of placenta growth factor in proliferative diabetic retinopathy. Lab Invest 1998; 78: 109–116 CAS PubMed Google Scholar Spirin KS, Saghizadeh M, Lewin SL, Zardi L, Kenney MC, Ljubimov AV . Basement membrane and growth factor gene expression in normal and diabetic human retinas. Curr Eye Res 1999; 18: 490–499 CAS PubMed Google Scholar Simpson DA, Murphy GM, Bhaduri T, Gardiner TA, Archer DB, Stitt AW . Expression of the VEGF gene family during retinal vaso-obliteration and hypoxia. Biochem Biophys Res Commun 1999; 262: 333–340 CAS PubMed Google Scholar Yonekura H, Sakurai S, Liu X, Migita H, Wang H, Yamagishi S et al. Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem 1999; 274: 35172–35178 CAS PubMed Google Scholar Tallquist MD, Soriano P, Klinghoffer RA . Growth factor signaling pathways in vascular development. Oncogene 1999; 18: 7917–7932 CAS PubMed Google Scholar Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V et al. Isolation of angiopoietin-1, a ligand for the Tie2 receptor, by secretion-trap expression cloning. Cell 1996; 87: 1161–1169 CAS PubMed Google Scholar Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55–60 CAS PubMed Google Scholar Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S et al. Requisite role of angiopoietin-1, a ligand for the Tie2 receptor, during embryonic angiogenesis. Cell 1997; 87: 1171–1180 Google Scholar Hayes AJ, Huang WQ, Mallah J, Yang D, Lippman ME, Li LY . Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells. Microvasc Res 1999; 58: 224–237 CAS PubMed Google Scholar Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W . Angiopoietin-1 induces sprouting angiogenesis in vitro. Curr Biol 1998; 8: 529–532 CAS PubMed Google Scholar Kukk E, Wartiovaara U, Gunji Y, Kaukonen J, Buhring HJ, Rappold I et al. Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells. Br J Haematol 1997; 98: 195–203 CAS PubMed Google Scholar Stratmann A, Risau W, Plate KH . Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am J Pathol 1998; 153: 1459–1466 CAS PubMed PubMed Central Google Scholar Hackett SF, Ozaki H, Strauss RW, Wahlin K, Suri C, Maisonpierre P et al. Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J Cell Physiol 2000; 184: 275–284 CAS PubMed Google Scholar Oh H, Takagi H, Suzuma K, Otani A, Matsumura M, Honda Y . Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells. J Biol Chem 1999; 274: 15732–15739 CAS PubMed Google Scholar Tombran-Tink J, Chader GG, Johnson LV . PEDF—a pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 1991; 53: 411–414 CAS PubMed Google Scholar Chader GJ . PEDF: raising both hopes and questions in controlling angiogenesis. Proc Natl Acad Sci USA 2001; 98: 2122–2124 CAS PubMed PubMed Central Google Scholar Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu HJ, Bendict W, Bouck NP . Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999; 285: 245–248 CAS PubMed Google Scholar Spranger J, Osterhoff M, Reimann M, Mohlig M, Ristow M, Francis MK et al. Loss of the anti-angiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Diabetes 2001; 50: 2641–2645 CAS PubMed Google Scholar Stellmach V, Crawford SE, Zhou W, Bouck N . Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Nat Acad Sci USA 2001; 98: 2593–2597 CAS PubMed PubMed Central Google Scholar Mori K, Duh E, Gehlbach P, Ando A, Takahashi K, Pearlman J et al. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J Cell Physiol 2001; 188: 253–263 CAS PubMed Google Scholar Which pathologic change is the cause of microaneurysms?Hyperglycemia results in damage to retinal capillaries through the formation of advanced glycation endproducts (AGEs). The resulting endothelial damage compromises capillary walls and results in microaneurysms.
Which risk factors is associated with macrovascular complications of diabetes mellitus?The strongest risk factors for CVD and mortality in T1D continue to be hyperglycemia, hypertension, dyslipidemia, diabetic kidney disease, insulin resistance and obesity (5–7).
What are the microvascular complications of diabetes?Definitions. Microvascular complications of diabetes are those long-term complications that affect small blood vessels. These typically include retinopathy, nephropathy, and neuropathy. Retinopathy is divided into two main categories: Nonproliferative retinopathy and proliferative retinopathy.
Which complication of diabetes can cause hypoglycemic unawareness?In insulin-deficient diabetes (exogenous) insulin levels do not decrease as glucose levels fall, and the combination of deficient glucagon and epinephrine responses causes defective glucose counterregulation. Reduced sympathoadrenal responses cause hypoglycemia unawareness.
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Which pathologic change is the cause of microaneurysms in nonproliferative retinopathy
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