Carbonic acid- bicarbonate- Carbonic acid is blood plasma, it is a week acid and it will gobble up hydroxide and make bicarbonate ion and water. If you have a bicarbonate ion that is a weak base and will gobble up hydronium and make carbonic acid. So by having both carbonic and bicarbonate the blood plasma is resistant to change in pH.
Phosphate you have dibasic potassium phosphate and monobasic potassium phosphate. The dibasic is a weak base, it gobbles up acid. Monobasic is an acid it gobbles up hydroxide and the others a weak acid it gobbles up base. As long as you have both in solution it resists becoming acidic or basic.
Proteins- some amino acids function as weak acids and will take out base, some act as weak bases and will take out hydronium. Because of a lot of amino acids in solution in cytoplasim it tends to buffer cytoplasim.
Hemoglobin- oxyhemoglobin is a weak base; it has a tendency to latch on to hydronium and taking that out of solution and by doing that it knocks that oxygen off the oxyhemoglobin. Present oxyhemoglobin to acid it drops off oxygen grabs the acid. So not only buffers the blood it helps release the oxygen under metabolically active conditions.
1) Fluid balances with constant osmolarity occur when isotonic fluid is lost or gained
- Volume depletion: isotonic fluid loss is greater than isotonic fluid gain (ex: severe burns, vomiting, diarrhea, or hyposecretion of aldosterone (hormone that stimulates Na+ and water reabsorption in kidney)
- Volume excess: occurs when isotonic fluid gain is greater than isotonic fluid loss. Typically results when fluid intake is normal, but there is decreased fluid loss through kidneys
2) Fluid imbalance with changes in osmolarity:
- Dehydration: water loss that is greater than solute loss (Ex: profuse sweating, diabetes, alcohol intake, hyposecretion of ADH). Water moves between fluid compartments with a net movement of water from cells into the iF and then into blood plasma
- Hypotonic hydration: Water intoxication, water gain greater than solute gain. (ex: ADH hyper secretion, too much plain water) . Brain cells can become impaired.
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