Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - original draft Show
1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Search for other works by this author on: This Site PubMed Google Scholar Caroline E. Sutton, Caroline E. Sutton Conceptualization, Investigation, Methodology, Project administration, Visualization, Writing - original draft 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Search for other works by this author on: This Site PubMed Google Scholar Kristin Ladell, Kristin Ladell Formal analysis, Investigation, Visualization 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK Search for other works by this author on: This Site PubMed Google Scholar Emma J. Grant  Emma J. Grant Formal analysis, Investigation, Visualization 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK 3 Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia Search for other works by this author on: This Site PubMed Google Scholar James E. McLaren James E. McLaren Formal analysis, Investigation, Validation, Visualization 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK Search for other works by this author on: This Site PubMed Google Scholar Fiona Roche Fiona Roche Data curation, Formal analysis, Resources, Visualization, Writing - original draft 4 Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland Search for other works by this author on: This Site PubMed Google Scholar Pradyot Dash Pradyot Dash Data curation, Formal analysis, Investigation, Methodology, Validation, Writing - original draft 5 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN Search for other works by this author on: This Site PubMed Google Scholar Nopporn Apiwattanakul Nopporn Apiwattanakul Methodology 5 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 6 Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Search for other works by this author on: This Site PubMed Google Scholar Walid Awad, Walid Awad Investigation 5 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN Search for other works by this author on: This Site PubMed Google Scholar Kelly L. Miners Kelly L. Miners Investigation, Methodology 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK Search for other works by this author on: This Site PubMed Google Scholar Stephen J. Lalor Stephen J. Lalor Methodology 7 Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Search for other works by this author on: This Site PubMed Google Scholar Julie C. Ribot, Julie C. Ribot Investigation 8 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Search for other works by this author on: This Site PubMed Google Scholar Song Baik Song Baik Data curation, Investigation 9 Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham, UK Search for other works by this author on: This Site PubMed Google Scholar Barry Moran, Barry Moran Data curation, Resources 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Search for other works by this author on: This Site PubMed Google Scholar Aoife McGinley Aoife McGinley Investigation 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Search for other works by this author on: This Site PubMed Google Scholar Valerie Pivorunas, Valerie Pivorunas Formal analysis, Investigation, Methodology 10 AbbVie Bioresearch Center, Inc., Worcester, MA Search for other works by this author on: This Site PubMed Google Scholar Lori Dowding, Lori Dowding Investigation 10 AbbVie Bioresearch Center, Inc., Worcester, MA Search for other works by this author on: This Site PubMed Google Scholar Michael Macoritto, Michael Macoritto Methodology 10 AbbVie Bioresearch Center, Inc., Worcester, MA Search for other works by this author on: This Site PubMed Google Scholar Jesus Paez-Cortez, Jesus Paez-Cortez Methodology 10 AbbVie Bioresearch Center, Inc., Worcester, MA Search for other works by this author on: This Site PubMed Google Scholar Anthony Slavin Anthony Slavin Funding acquisition, Project administration, Resources, Supervision 10 AbbVie Bioresearch Center, Inc., Worcester, MA Search for other works by this author on: This Site PubMed Google Scholar Graham Anderson Graham Anderson Investigation, Visualization 9 Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham, UK Search for other works by this author on: This Site PubMed Google Scholar Bruno Silva-Santos Bruno Silva-Santos Conceptualization, Supervision 8 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Search for other works by this author on: This Site PubMed Google Scholar Karsten Hokamp, Karsten Hokamp Data curation, Formal analysis, Resources, Visualization, Writing - original draft 4 Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland Search for other works by this author on: This Site PubMed Google Scholar David A. Price David A. Price Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK Search for other works by this author on: This Site PubMed Google Scholar Paul G. Thomas Paul G. Thomas Funding acquisition, Project administration, Resources, Supervision 5 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN Search for other works by this author on: This Site PubMed Google Scholar Rachel M. McLoughlin, Rachel M. McLoughlin Conceptualization, Methodology, Project administration, Supervision 7 Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Search for other works by this author on: This Site PubMed Google Scholar Kingston H.G. Mills Kingston H.G. Mills Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Correspondence to Kingston H.G. Mills: [email protected] Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information Sarah C. Edwards 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Caroline E. Sutton Conceptualization, Investigation, Methodology, Project administration, Visualization, Writing - original draft 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Kristin Ladell Formal analysis, Investigation, Visualization 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK Emma J. Grant 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK 3 Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia James E. McLaren 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK Fiona Roche 4 Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland Pradyot Dash 5 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN Nopporn Apiwattanakul 5 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 6 Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Walid Awad Investigation 5 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN Kelly L. Miners 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK Stephen J. Lalor 7 Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Julie C. Ribot Investigation 8 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Song Baik 9 Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham, UK Barry Moran Data curation, Resources 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Aoife McGinley 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Valerie Pivorunas Formal analysis, Investigation, Methodology 10 AbbVie Bioresearch Center, Inc., Worcester, MA Lori Dowding Investigation 10 AbbVie Bioresearch Center, Inc., Worcester, MA Michael Macoritto Methodology 10 AbbVie Bioresearch Center, Inc., Worcester, MA Jesus Paez-Cortez Methodology 10 AbbVie Bioresearch Center, Inc., Worcester, MA Anthony Slavin 10 AbbVie Bioresearch Center, Inc., Worcester, MA Graham Anderson 9 Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Medical School, University of Birmingham, Edgbaston, Birmingham, UK Bruno Silva-Santos 8 Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Karsten Hokamp Data curation, Formal analysis, Resources, Visualization, Writing - original draft 4 Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland David A. Price 2 Division of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK Paul G. Thomas 5 Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN Rachel M. McLoughlin Conceptualization, Methodology, Project administration, Supervision 7 Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Kingston H.G. Mills 1 Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland Correspondence to Kingston H.G. Mills: [email protected] Disclosures: Dr. Edwards reported grants from Abbvie during the conduct of the study. Dr. Thomas reported a patent to PCT/US2016/064735 pending. Dr. Mills reported grants from Abbvie during the conduct of the study and personal fees from Pieris outside the submitted work. In addition, Dr. Mills had a patent on IL-17 inhibitors pending. No other disclosures were reported. * S.C. Edwards and C.E. Sutton contributed equally to this paper. Received: May 09 2019 Revision Received: November 29 2019 Accepted: January 17 2020 Online Issn: 1540-9538 Print Issn: 0022-1007 Funding Funder(s): Science Foundation Ireland
Funder(s): AbbVie Funder(s): Irish Higher Education Authority Program for Research in Third-Level Institutions Funder(s): National Health and Medical Research Council Funder(s): European Research Council
Funder(s): Medical Research Council
Funder(s): Wellcome Trust
Funder(s): National Institutes of Health
Funder(s): American Lebanese Syrian Associated Charities © 2020 Edwards et al. 2020 This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). Which of the following best predicts why humans and mice have identical telomeric repeat sequences?Which of the following best predicts why humans and mice have identical telomeric repeat sequences? Humans and mice share a recent common ancestor that had the 5′-TTAGGG-3′ repeat sequence in its telomeres.
Which of the following represents an alternate hypothesis tested by this experiment with regard to the population sizes of Henslow's sparrows?Which of the following represents an alternate hypothesis tested by this experiment with regard to the population sizes of Henslow's sparrows? Controlled fires in counties 4 and 5 will lead to an increase in the sparrow population.
Which of the following best predicts the result of the bacteria failing to uptake the recombinant plasmid?Which of the following best predicts the result of the bacteria failing to uptake the recombinant plasmid? The bacterial cell will stop producing bacterial proteins.
Which of the following best explains the relationship between coat color and predation rate?A dark coat color provides camouflage to mice on the lava flow rocks; therefore, mice with dark coats have a lower predation rate in that habitat.
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A population geneticist is conducting an investigation on a population of mice
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